An efficient synthesis of the tamandarin B macrocycle

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Concise Synthesis of Tetrazole Macrocycle

A concise two step synthesis of tetrazole containing macrocycles from readily accessible starting materials is presented. The first step comprises a chemoselective amidation of amino acid derived isocyanocarboxylicacid esters with unprotected symmetrical diamines to afford diverse α-isocyano-ω-amines. In the second step, the α-isocyano-ω-amines undergo an Ugi tetrazole reaction to close the mac...

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Part I. Synthetic Investigations of Heterocyclic Natural and Unnatural Compounds Part Ii. New Approach to Latent Fingerprint Detection on Paper Copyright© 2014

........................................................................................................ VI CHAPTER 1 DIDEMNINS, TAMANDARINS, AND RELATED NATURAL PRODUCTS ....................................................................................... 1 1.1. Discovery and isolation ....................................................................................... 1 1.2. Structural f...

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ژورنال

عنوان ژورنال: Tetrahedron Letters

سال: 2010

ISSN: 0040-4039

DOI: 10.1016/j.tetlet.2009.12.091